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How COSELATM can help

COSELA™ (trilaciclib) is given before chemotherapy (on each day you get chemo) to help reduce the occurence of low blood cell counts caused by damage to bone marrow from chemo.

Read more about how chemo can damage your bone marrow

How does it work?

While chemo is working to destroy cancer cells, COSELA helps keep chemo from damaging your bone marrow. Helping to protect the “parent cells” in your bone marrow may help keep your white and red blood cell counts from dropping too low, which is what can cause neutropenia and anemia. This proactive protection of the bone marrow is what doctors call “myeloprotection.”

After your treatment with COSELA and chemo is done, your bone marrow can start making your white and red blood cells again.

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During CHEMO

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Simply put...

COSELA helps protect your bone marrow from damage during chemo, so some of your blood cell counts might not drop too low.

How could COSELA work for you?

COSELA is given to help reduce the occurence of low blood cell counts caused by damage to bone marrow during chemotherapy. COSELA was studied in 3 clinical trials in people who were diagnosed with extensive-stage small cell lung cancer. The people were divided into two groups: some people were given COSELA before their chemo, and some were not. This was so researchers could determine the effects of COSELA.

The main trial of COSELA + chemo (etoposide, carboplatin, and atezolizumab) found a 96% reduction in severe neutropenia.

SEVERENEUTROPENIA19%SEVEREANEMIA49.1%Chemo(53 people)28%Chemo(53 people)1.9%COSELA + Chemo(54 people)COSELA + Chemo(54 people)96%REDUCTION SEVERENEUTROPENIA1.9%COSELA + Chemo(54 people)96%REDUCTION49.1%Chemo(53 people) 19%COSELA + Chemo(54 people)28%Chemo(53 people)SEVEREANEMIA

Severe neutropenia is a very low white blood cell count.

Severe anemia is a very low red blood cell count.

In clinical trials, the most common side effects that people experienced were fatigue; low levels of calcium, potassium, or phosphate in your blood; high levels of a liver enzyme; headache; infection in the lungs (pneumonia); rash; reactions related to the infusion; swelling in the legs or arms; stomach pain; blood clots; and a high blood sugar level. These are not all the side effects of COSELA.

Chemo dose reductions

In this study, the rate of chemo dose reductions was lower in people taking COSELA.

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Good to know:

Not having to reduce the chemo dose may help you stay on track with your scheduled treatment plan.

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